Spider-Man 2099 holds an awkward place as the only Leadership Web-Warrior, but there are plenty of Basic Web-Warrior allies to play in a deck with him, or you can make him part of a multiplayer team. Miguel is under-statted for an ally, though there are ways to cheat him into play like Call for Backup and Across the Spider-Verse. From an efficiency perspective, the response ability is usually not worth it. The ability of an ally to block a villain's attack with their last hit point is a huge part of their value (~2 ER). By returning that ally to hand, we only give ourselves 1 ER of value. So why would we ever do this? (and before you say Web of Life and Destiny, remember you draw the card either way) First of all, this grants flexibility. If we have a resource-heavy hand in which 2+ resources would go unspent, we can return a playable ally to hand, then the "loss" of 1 ER of value is still less than the 2+ ER that would otherwise be wasted. Web-Warriors with strong enters play abilities like Miles or Pavitr might also be worth replaying again even at 1 ER less than their usual value.
Most notably, Miguel makes a powerful loop with Madame Web, which can let you stack the encounter deck several turns in a row. It's expensive to get going, but once it is, it becomes basically impossible to lose the game.
This is a pretty clean implementation of the core deck idea by theromeo3517 if you want to take 2099 out for a spin: marvelcdb.com
Spider-Man 2099 is a bit overrated for my money, but he certainly defines a unique and interesting deck, especially for coordinated multiplayer Web-Warrior lineups.