Armed to the Teeth and Claws

Sure with:

-Genius package: Ingenuity + Moon Girl for economy.

-Dora Milaje Package because it's they are good on their own but also power The Elephant's Trunk. Team-Building Exercise can help get them out. It has additional synergy here, discussed below.

-Lots of economy!! You have: Avengers Mansion, Helicarrier, Team-Building Exercise, The Elephant's Trunk, Ingenuity, Shuri's Alter-Ego ability, 2 Vibranium, Moon Girl, Nick Fury, and a The Power in All of Us which works on tons of stuff in this deck.

-Everyone is packin' weapons! So, you'll usually want Panther Claws because it will immediately power Mean Swing and Firepower. You have 3 copies of Sidearm for you Dora Milaje allies which tend to stick around for extra damage. You have additionally have a Hand Cannon (for damage + overkill) and Plasma Rifle (to ping toughs). Both are weapons and both are tech for Shuri to find as necessary to power Firepower.

Once you have weapons in play, you should focus on getting Kimoyo Beads to help with thwarting, because killing should be no problem.

If you think there's too much economy, sub in readies (Tenacity or Ready to Rumble) or Aggressive Energy/Warrior Skill for additional damage on Firepower (I think that works?)

Now I see why in the MCU movies Shuri blasts s#$%!