Float Like an Airship

Pericles

The general idea here is that you use Maria's Alter Ego ability to get The Pericles out early.

This should allow you to reliably confuse the villain every turn for the rest of the game (provided they don't have steady or stalwart, obviously), and put a status on a minion or ally to boot.

To keep activating Pericles sustainably, be sure to get S.H.I.E.L.D. Director or a S.H.I.E.L.D. Support with some counters on it out ASAP (Using your mulligan to try and find Special Funding on the first turn can also be helpful in this regard).

Confusion Synergy

Once this is set up, Cypher, Chamber, Spider-Woman, Scare Tactic, and Float Like a Butterfly help you get great value from the confusion.

Additionally,Field Agent and Command Team pull double duty as counter batteries and as tools to get more from your allies.

Maria

Maria is one of my favorite hero designs in a while and I'm very excited to see what people do with her. Have fun playing!