"お前はもう死んでる！"- Gambit (Probably)

Oh, you want to hit Gambit? Too bad.

If things come up neatly, you can defend and deal 50+ damage.

Rules:

1. Don't spend all your energy counters in one place, let them stack a little if you don't need them.
2. Keep the money train rolling with perfectly sized hits from First Hit using your charge bank to trigger Change of Fortune.
3. Gambit's base defense plus Defensive Conditioning and Armored Vest make him essentially invulnerable to most Villains on Standard and you have plenty of ways to increase that.
4. Use Jocasta to hold Natural Agility.

Congratulations, your Natural Agility plus "Stop Hitting Yourself" can now blast out a lot of damage. It's entirely possible with your deck thinned from playing upgrades that you hit both copies of Natural Agility and 2 "Stop Hitting Yourself" which will summarily execute the villain.

Firm handshakes all 'round. This is my favorite protection deck I have ever built.