SS Economy + GL Lockdown

This deck is all about side scheme economy and Global Logistics lockdown.

Side Scheme Economy:

First, this deck takes advantage of getting to use both Skilled Investigator and Mission Leader in one deck. Each time you defeat a side scheme, you draw 2 cards!

To guarantee you have side schemes to defeat, the deck runs 5 player side schemes and a copy of One Way or Another. Unlike other heroes / decks, you are not looking to complete these side schemes as quickly as possible to set yourself up — instead, you are looking to complete one per turn, so you are always triggering Skilled Investigator and Mission Leader.

Speaking of economy, do not be afraid to use Clarity of Purpose as often as possible. If the villain is stunned and confused, you may not be taking any damage from attacks, and you want some damage to heal with Contaminant Immunity. Luckily, too, the wording is "deal 1 damage," so you can use Clarity of Purpose even when you are tough.

Global Logistics Lockdown

The other thing this deck takes advantage of is getting to use Global Logistics and The Triskelion in the same deck. You can always use The Triskelion to play Global Logistics, instead of having to use one of your characters or invest in other S.H.I.E.L.D. cards.

Additionally, because of Pheromones stunning and confusing the villain, it is very possible for you to determine 2-4 villain phases with a single copy of Global Logistics. To grease the wheels of this stun+confuse lockdown, there's a single copy of Upside the Head when you need it.

One of your best targets for Rapid Response may be Mockingbird, since she also contributes to keeping the villain stunned.

Multiplayer

If you use this deck in multiplayer, you can of course add 1-2 more copies of Skilled Investigator, just remember to add 1-2 Leadership cards. Keep them cheap and easy to play, perhaps even just more copies of Clarity of Purpose to play on your friends.