Spider-Ham "This is too easy!"

Get Clarity of Purpose as fast as possible. It basically will give 2 free resources each turn! Infinite money to pay for anything! Make sure to heal if you get too low on health (depending on the villain but I usually heal at 6 or below). Try to set up your Cartoon Physics upgrades as much as possible. You can always remove some cards such as Team Training, and Triskelion.